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检索条件"作者=Clarke, Colin"
1494 条 记 录,以下是31-40 订阅
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Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate
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BMC genomics 2012年 第1期13卷 656-656页
作者: Clarke, Colin Henry, Michael Doolan, Padraig Kelly, Shane Aherne, Sinead Sanchez, Noelia Kelly, Paul Kinsella, Paula Breen, Laura Madden, Stephen F. Zhang, Lin Leonard, Mark Clynes, Martin Meleady, Paula Barron, Niall Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Dublin City Univ Dublin 9 Ireland Pfizer Inc Bioproc R&D Andover MA USA
Background: To study the role of microRNA (miRNA) in the regulation of Chinese hamster ovary (CHO) cell growth, qPCR, microarray and quantitative LC-MS/MS analysis were utilised for simultaneous expression profiling o... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 springerlink期刊 springerlink期刊 ebsco(ASP/aph) ebsco(MEDLINE/cmedm) 评论
Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer
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International Journal of Cancer 2012年 第4期131卷 911-923页
作者: Dowling, Paul Clarke, Colin Hennessy, Kim Torralbo-Lopez, Beatriz Ballot, Jo Crown, John Kieman, Ingrid O'Byrne, Kenneth J. Kennedy, M. John Lynch, Vincent Clynes, Martin Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland All Ireland Cooperat Oncol Res Grp ICORG Dublin 2 Ireland St Vincents Univ Hosp Dublin 4 Ireland St James Hosp Trinity Ctr Hlth Sci Inst Mol Med Dept Clin MedTranslat Canc Res Grp Dublin 8 Ireland Univ Dublin Trinity Coll Dublin 2 Ireland St James Hosp Acad Unit Clin & Mol Oncol Dublin 8 Ireland MTCI Dublin Ireland
Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have prev... 详细信息
来源: Wiley期刊 Wiley期刊 评论
Bromodomain and Extraterminal Proteins Suppress NF-E2-Related Factor 2-Mediated Antioxidant Gene Expression
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Journal of immunology (Baltimore, Md. : 1950) 2014年 第10期192卷 4913-4920页
作者: Michaeloudes, Charalambos Mercado, Nicolas Clarke, Colin Bhavsar, Pankaj K. Adcock, Ian M. Barnes, Peter J. Chung, Kian Fan Univ London Imperial Coll Sci Technol & Med Natl Heart & Lung Inst Airway Dis Sect London SW3 6LY England Royal Brompton Hosp Biomed Res Unit London SW3 6LY England
Oxidative stress, a pathogenetic factor in many conditions, including chronic obstructive pulmonary disease, arises due to accumulation of reactive oxygen species and defective antioxidant defenses in the lungs. The l... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(MEDLINE/cmedm) ebsco(ASP/aph) 评论
Metabolomic and proteomic analysis of breast cancer patient samples suggests that glutamate and 12-HETE in combination with CA15-3 may be useful biomarkers reflecting tumour burden
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Metabolomics 2015年 第3期11卷 620-635页
作者: Dowling, Paul Henry, Michael Meleady, Paula Clarke, Colin Gately, Kathy O'Byrne, Kenneth Connolly, Elizabeth Lynch, Vincent Ballot, Jo Gullo, Giuseppe Crown, John Moriarty, Michael Clynes, Martin Natl Univ Ireland Maynooth Dept Biol Maynooth Kildare Ireland Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland St James Hosp Trinity Coll Dublin Trinity Ctr Hlth Sci Inst Mol Med Dublin 8 Ireland St James Hosp Dept Surg Dublin 8 Ireland St Vincents Univ Hosp MTCI Dublin 4 Ireland
Evaluation of protein and metabolite expression patterns in blood using mass spectrometry and high-throughput antibody-based screening platforms has potential for the discovery of new biomarkers for managing breast ca... 详细信息
来源: springerlink期刊 springerlink期刊 EBSCOASC期刊 EBSCOASC期刊 评论
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
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Genome Biology 2006年 第10期7卷 R100-R100页
作者: Carpenter, Anne E. Jones, Thouis Ray Lamprecht, Michael R. Clarke, Colin Kang, In Han Friman, Ola Guertin, David A. Chang, Joo Han Lindquist, Robert A. Moffat, Jason Golland, Polina Sabatini, David M. Whitehead Inst Biomed Res Cambridge MA 02142 USA MIT Comp Sci & Artificial Intelligence Lab Cambridge MA 02142 USA Brigham & Womens Hosp Dept Radiol Boston MA 02115 USA MIT Dept Biol Cambridge MA 02142 USA
Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference). Here we describe the first free, open-source... 详细信息
来源: springerlink期刊 springerlink期刊 评论
A novel panel of protein biomarkers for predicting response to thalidomide-based therapy in newly diagnosed multiple myeloma patients
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Proteomics 2011年 第8期11卷 1391-1402页
作者: Rajpal, Rajesh Dowling, Paul Meiller, Justine Clarke, Colin Murphy, William G. O'Connor, Robert Kell, Malcolm Mitsiades, Constantine Richardson, Paul Anderson, Kenneth C. Clynes, Martin O'Gorman, Peter Dublin City Univ NICB Dublin 9 Ireland Mater Misericordiae Univ Hosp Dept Hematol Dublin 7 Ireland Irish Blood Transfus Serv Dublin Ireland Dublin City Univ Sch Nursing Dublin 9 Ireland Univ Coll Dublin Dublin Acad Med Ctr Dublin 2 Ireland Dana Farber Canc Inst Boston MA 02115 USA
Multiple myeloma (MM) is a heterogeneous group of disorders both genotypically and phenotypically. Response to thalidomide-based induction therapy in newly diagnosed patients varies significantly in published clinical... 详细信息
来源: Wiley期刊 Wiley期刊 评论
Polyclonal Immunoglobulin G N-Glycosylation in the Pathogenesis of Plasma Cell Disorders
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Journal of Proteome Research 2017年 第2期16卷 748-762页
作者: Mittermayr, Stefan Le, Giao N. Clarke, Colin Martin, Silvia Millan Larkin, Anne-Marie O'Gorman, Peter Bones, Jonathan NIBRT Foster Ave Dublin A94 X099 Blackrock Co Ireland Mater Misericordiae Univ Hosp Dept Haematol Dublin D07 R2WY Ireland Dublin City Univ Natl Inst Cellular Biotechnol Dublin D09 NR58 Ireland
The pathological progression from benign monoclonal gammopathy of undetermined significance (MGUS) to smoldering myeloma (SMM) and finally to active myeloma (MM) is poorly understood. Abnormal immunoglobulin G (IgG) g... 详细信息
来源: ACS期刊 ebsco(MEDLINE/cmedm) 评论
Raman spectroscopy - a potential platform for the rapid measurement of carbon nanotube-induced cytotoxicity
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The Analyst 2009年 第6期134卷 1182-1191页
作者: Knief, Peter Clarke, Colin Herzog, Eva Davoren, Maria Lyng, Fiona M. Meade, Aidan D. Byrne, Hugh J. Dublin Inst Technol Sch Phys Focas Res Inst Dublin 8 Ireland Dublin Inst Technol Focas Res Inst Radiat & Environm Sci Ctr Dublin 8 Ireland
In this study the suitability of Raman spectroscopy for the determination of carbon nanotube mediated toxicity on human alveolar carcinoma epithelial cells (A549) is explored. The exposure of this cell line represents... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 英国皇家化学学会(RSC... ebsco(ASP/aph) 评论
MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3
PLOS ONE
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PLOS ONE 2013年 第6期8卷 e65671页
作者: Sanchez, Noelia Gallagher, Mark Lao, Nga Gallagher, Clair Clarke, Colin Doolan, Padraig Aherne, Sinead Blanco, Alfonso Meleady, Paula Clynes, Martin Barron, Niall Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Univ Coll Dublin Conway Inst Dublin 2 Ireland
MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) ebsco(MEDLINE/cmedm) 评论
Does a standardised scoring system of clinical signs reduce variability between doctors' assessments of the potentially dehydrated child?
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Journal of Paediatrics and Child Health 2010年 第3期46卷 103-107页
作者: Roland, Damian Clarke, Colin Borland, Meredith L. Pascoe, Elaine M. Leicester Royal Infirm Emergency Dept Registrars Off Leicester LE1 5WW Leics England Royal Perth Hosp Emergency Dept Perth WA Australia Princess Margaret Hosp Children Div Clin Res & Educ Perth WA Australia Univ Western Australia Sch Paediat & Child Hlth Nedlands WA 6009 Australia
Aims: Clinical assessment of dehydration in children is often inaccurate. We aimed to determine if a scoring system based on standardised clinical signs would reduce the variability between doctors' assessment of dehy... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) 评论