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检索条件"作者=Clarke, Colin"
1494 条 记 录,以下是1-10 订阅
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Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq
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Biotechnology and bioengineering 2019年 第6期116卷 1556-1562页
作者: Clarke, Colin Gallagher, Clair Kelly, Ronan M. Henry, Michael Meleady, Paula Frye, Christopher C. Osborne, Matthew D. Brady, Ciaran P. Barron, Niall Clynes, Martin Natl Inst Bioproc Res & Training Fosters Ave Blackrock Dublin Ireland Dublin City Univ Natl Inst Cellular Biotechnol Dublin Ireland Eli Lilly & Co LTC North Bioproc Res & Dev Bioproc Res & Dev Indianapolis IN 46285 USA Eli Lilly SA Biotech Tech Serv Mfg Sci Irish Branch Cork Ireland Univ Coll Dublin UCD Engn & Mat Sci Ctr UCD Sch Chem & Bioproc Engn Dublin Ireland
In this study, we report an investigation of a panel of clonally-derived Chinese hamster ovary (CHO) cell lines exhibiting variability in the proportion of full-length IgG4 Fc-fusion protein produced. The recombinant ... 详细信息
来源: Wiley期刊 Wiley期刊 评论
Predicting cell-specific productivity from CHO gene expression
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Microbiol Immunol 2011年 第2期151卷 159-165页
作者: Clarke, Colin Doolan, Padraig Barron, Niall Meleady, Paula O'Sullivan, Finbarr Gammell, Patrick Melville, Mark Leonard, Mark Clynes, Martin Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Pfizer Inc BioMfg Sci Grp Dublin 22 Ireland Pfizer Inc Bioproc R&D Andover MA 01810 USA
Improving the rate of recombinant protein production in Chinese hamster ovary (CHO) cells is an important consideration in controlling the cost of biopharmaceuticals. We present the first predictive model of productiv... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... ebsco(ASP/aph) EBSCOASC期刊 EBSCOASC期刊 ebsco(MEDLINE/cmedm) 评论
Stationarity of AMAX series of short-duration rainfall for long-term Canadian stations: detection of jumps and trends
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Canadian Journal of Civil Engineering 2011年 第11期38卷 1175-1184页
作者: Clarke, Colin Hulley, Mike Marsalek, Jiri Watt, Ed Royal Mil Coll Canada Stn Forces Kingston ON K7K 7B4 Canada XCG Consultants Ltd Kingston ON K7K 1Z7 Canada Environm Canada Burlington ON L7R 4A6 Canada Queens Univ Kingston ON K7L 3N6 Canada
Short-duration rainfall data are key inputs for design of stormwater infrastructure. To address concerns raised regarding the validity of relations based on these data, 13 Canadian climate stations were selected: one ... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) 评论
Occurrence and magnitude of low flows for Canadian rivers: an ecozone approach
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Canadian Journal of Civil Engineering 2014年 第1期41卷 1-8页
作者: Hulley, Mike Clarke, Colin Watt, Ed Royal Mil Coll Canada Dept Civil Engn Kingston ON K7K 7B4 Canada XCG Consultants Ltd Kingston ON K7K 1Z7 Canada Queens Univ Dept Civil Engn Kingston ON K7L 3N6 Canada
Low-flow occurrence and magnitude have been documented for Canada using the National Ecological Framework. The low flow database is composed of the 7-day low flow with 2-year return period (7Q(2)) values for 453 natur... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) 评论
Processing ThinPrep cervical cytological samples for Raman spectroscopic analysis
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Analytical Methods 2014年 第19期6卷 7831-7841页
作者: Bonnier, Franck Traynor, Damien Kearney, Padraig Clarke, Colin Knief, Peter Martin, Cara O'Leary, John J. Byrne, Hugh J. Lyng, Fiona Dublin Inst Technol Ctr Radiat & Environm Sci Focas Res Inst Dublin 8 Ireland Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Coombe Women & Infants Univ Hosp Dept Pathol Dublin Ireland Dublin Inst Technol Focas Res Inst Dublin 8 Ireland
Raman microspectroscopy has been proven to be a promising technique for diagnosis and early detection of pathologies. The data collected delivers a chemical fingerprint allowing the identification of specific biomarke... 详细信息
来源: 英国皇家化学学会(RSC... 评论
Transcriptomic analysis of clonal growth rate variation during CHO cell line development
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Microbiol Immunol 2013年 第3期166卷 105-113页
作者: Doolan, Padraig Clarke, Colin Kinsella, Paula Breen, Laura Meleady, Paula Leonard, Mark Zhang, Lin Clynes, Martin Aherne, Sinead T. Barron, Niall Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Pfizer Inc Bioproc R&D Andover MA 01810 USA
The selection of clones displaying a high rate of cell growth is an essential component of Chinese hamster ovary (CHO) cell line development. In recent years various "omics" technologies have been utilised to understa... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) ebsco(MEDLINE/cmedm) 评论
CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors
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Biotechnology journal 2014年 第3期9卷 396-404页
作者: Sanchez, Noelia Kelly, Paul Gallagher, Clair Lao, Nga T. Clarke, Colin Clynes, Martin Barron, Niall Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland
Improving the efficiency of recombinant protein production by CHO cells is highly desirable as more complex proteins (MAbs, fusion proteins, blood/clotting factors, etc.) go into development and come onto the market. ... 详细信息
来源: Wiley期刊 Wiley期刊 ebsco(MEDLINE/cmedm) 评论
Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells
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Metabolic engineering 2017年 41卷 11-22页
作者: Kelly, Paul S. Clarke, Colin Costello, Alan Monger, Craig Meiller, Justine Dhiman, Heena Borth, Nicole Betenbaugh, Michael J. Clynes, Martin Barron, Niall Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Natl Inst Bioproc Res & Training Fosters Ave Blackrock Dublin Ireland Univ Nat Resources & Life Sci Muthgasse 18 A-1190 Vienna Austria Johns Hopkins Univ Dept Chem & Biomol Engn Baltimore MD USA
Recent sequencing of the Chinese hamster ovary (CHO) cell and Chinese hamster genomes has dramatically advanced our ability to understand the biology of these mammalian cell factories. In this study, we focus on the p... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... EBSCOASC期刊 EBSCOASC期刊 ebsco(ASP/aph) ebsco(MEDLINE/cmedm) 评论
Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
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Biotechnology and bioengineering 2012年 第6期109卷 1386-1394页
作者: Meleady, Paula Hoffrogge, Raimund Henry, Michael Rupp, Oliver Bort, Juan Hernandez Clarke, Colin Brinkrolf, Karina Kelly, Shane Mueller, Benjamin Doolan, Padraig Hackl, Matthias Beckmann, Tim Frederik Noll, Thomas Grillari, Johannes Barron, Niall Puehler, Alf Clynes, Martin Borth, Nicole Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Univ Bielefeld Ctr Biotechnol D-33594 Bielefeld Germany Univ Bodenkultur Vienna BOKU Dept Biotechnol Vienna Austria ACIB Austrian Ctr Ind Biotechnol A-1190 Vienna Austria
Recently released sequence information on Chinese hamster ovary (CHO) cells promises to not only facilitate our understanding of these industrially important cell factories through direct analysis of the sequence, but... 详细信息
来源: Wiley期刊 Wiley期刊 ebsco(MEDLINE/cmedm) 评论
Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines
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Biotechnology journal 2012年 第4期7卷 516-526页
作者: Doolan, Padraig Barron, Niall Kinsella, Paula Clarke, Colin Meleady, Paula O'Sullivan, Finbarr Melville, Mark Leonard, Mark Clynes, Martin Dublin City Univ Natl Inst Cellular Biotechnol Dublin 9 Ireland Pfizer Inc Bioproc R&D Andover MA USA PERCIVIA LLC Cambridge MA USA
Fed batch culture processes are often characterized by decreasing cell culture performance as the process continues, presumably through the depletion of vital nutrients and the accumulation of toxic byproducts. We hav... 详细信息
来源: Wiley期刊 Wiley期刊 ebsco(MEDLINE/cmedm) 评论