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检索条件"作者=Cameron, Michael"
263 条 记 录,以下是1-10 订阅
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Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production
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Journal of Medicinal Chemistry 2021年 第2期64卷 980-990页
作者: Lin, Hua Sharabi, Kfir Lin, Li Ruiz, Claudia Zhu, Di Cameron, Michael D. Novick, Scott J. Griffin, Patrick R. Puigserver, Pere Kamenecka, Theodore M. Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA Fujian Normal Univ Coll Life Sci Biomed Res Ctr South China Fuzhou 350117 Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Cell Biol Boston MA 02115 USA
Despite a myriad of available pharmacotherapies for the treatment of type 2 diabetes (T2D), challenges still exist in achieving glycemic control. Several novel glucose-lowering strategies are currently under clinical ... 详细信息
来源: ACS期刊 评论
Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
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Neuropharmacology 2021年 185卷 108439页
作者: Pantouli, Fani Grim, Travis W. Schmid, Cullen L. Acevedo-Canabal, Agnes Kennedy, Nicole M. Cameron, Michael D. Bannister, Thomas D. Bohn, Laura M. Scripps Res Inst Dept Mol Med Jupiter FL USA Scripps Res Inst Dept Neurosci Jupiter FL USA Scripps Res Inst Dept Chem Jupiter FL USA
The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTP gamma S binding over beta arrestin2 recruitment in cellular assays, thereby demonstrating signaling bias. In mice, SR-17018 stimulates G... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... 评论
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition
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Science Advances 2020年 第25期6卷 1-15页
作者: Fassl, Anne Brain, Christopher Abu-Remaileh, Monther Stukan, Iga Butter, Deborah Stepien, Piotr Feit, Avery S. Bergholz, Johann Michowski, Wojciech Otto, Tobias Sheng, Qing Loo, Alice Michael, Walter Tiedt, Ralph DeAngelis, Carmine Schiff, Rachel Jiang, Baishan Jovanovic, Bojana Nowak, Karolina Ericsson, Maria Cameron, Michael Gray, Nathanael Dillon, Deborah Zhao, Jean J. Sabatini, David M. Jeselsohn, Rinath Brown, Myles Polyak, Kornelia Sicinski, Piotr Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Blavatn Inst Dept Genet Boston MA 02115 USA Novartis Inst Biomed Res Cambridge MA 02139 USA Whitehead Inst Biomed Res 9 Cambridge Ctr Cambridge MA 02142 USA MIT Cambridge MA 02142 USA Stanford Univ Dept Chem Engn Stanford CA 94305 USA Stanford Univ Dept Genet Stanford CA 94305 USA Stanford Univ Inst Chem Engn & Med Human Hlth ChEM H 290 Jane Stanford Way Stanford CA 94305 USA Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA Brigham & Womens Hosp Dept Med 75 Francis St Boston MA 02115 USA Harvard Med Sch Boston MA 02115 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02115 USA Novartis Inst Biomed Res Oncol Dis Area CH-4057 Basel Switzerland Baylor Coll Med Lester & Sue Smith Breast Ctr Houston TX 77030 USA Baylor Coll Med Dept Med Houston TX 77030 USA Baylor Coll Med Dept Mol & Cellular Biol Houston TX 77030 USA Univ Naples Federico II Dept Clin Med & Surg Naples Italy Harvard Med Sch Electron Microscopy Facil Boston MA 02115 USA Scripps Res Inst Dept Mol Therapeut Jupiter FL 33458 USA Brigham & Womens Hosp Dept Pathol 75 Francis St Boston MA 02115 USA Broad Inst Harvard & MIT Cambridge MA 02142 USA MIT Howard Hughes Med Inst Cambridge MA 02139 USA MIT Koch Inst Integrat Canc Res Cambridge MA 02142 USA
Inhibitors of cyclin-dependent kinases CDK4 and CDK6 have been approved for treatment of hormone receptor-positive breast cancers. In contrast, triple-negative breast cancers (TNBCs) are resistant to CDK4/6 inhibition... 详细信息
来源: 《科学》杂志 ebsco(ASP/aph) 评论
Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification
ACS Infectious Diseases
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ACS Infectious Diseases 2020年 第8期6卷 2169-2180页
作者: Wu, Zhi-Chen Cameron, Michael D. Boger, Dale L. Scripps Res Inst Dept Chem La Jolla CA 92037 USA Scripps Res Inst Skaggs Inst Chem Biol La Jolla CA 92037 USA Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA
A series of vancomycin C-terminus guanidine modifications is disclosed that improves antimicrobial activity, enhances the durability of antimicrobial action against selection or induction of resistance, and introduces... 详细信息
来源: ebsco(MEDLINE/cmedm) 评论
Jacobin Allegory in Thelwall's The Rock of Modrec
Romanticism
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Romanticism 2020年 第3期26卷 223-234页
作者: Cameron, Michael
This essay seeks to show that The Rock of Modrec occupies an important place in Thelwall's oeuvre and in the early development of Jacobin 'seditious allegory'. While scholarship has thus far ignored The Rock of Modrec... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 评论
Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
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Cancer Discovery 2019年 第7期9卷 926-943页
作者: To, Ciric Jang, Jaebong Chen, Ting Park, Eunyoung Mushajiang, Mierzhati De Clercq, Dries J. H. Xu, Man Wang, Stephen Cameron, Michael D. Heppner, David E. Shin, Bo Hee Gero, Thomas W. Yang, Annan Dahlberg, Suzanne E. Wong, Kwok-Kin Eck, Michael J. Gray, Nathanael S. Janne, Pasi A. Dana Farber Canc Inst Lowe Ctr Thorac Oncol Boston MA 02215 USA Dana Farber Canc Inst Dept Med Oncol Boston MA 02215 USA Harvard Med Sch Dept Med Boston MA 02115 USA Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02115 USA Belfer Ctr Appl Canc Sci Boston MA USA Scripps Res Inst Dept Mol Therapeut Jupiter FL USA Dana Farber Canc Inst Dept Biostat & Computat Biol Boston MA 02215 USA
Allosteric kinase inhibitors offer a potentially complementary therapeutic strategy to ATP-competitive kinase inhibitors due to their distinct sites of target binding. In this study, we identify and study a mutant-sel... 详细信息
来源: ebsco(MEDLINE/cmedm) 评论
Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models
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Molecular Pharmaceutics 2019年 第7期16卷 3065-3071页
作者: Su, Meng Qiu, Lin Deng, Youchao Ruiz, Claudia H. Rudolf, Jeffrey D. Dong, Liao-Bin Feng, Xueqiong Cameron, Michael D. Shen, Ben Duan, Yanwen Huang, Yong Cent S Univ Xiangya Int Acad Translat Med Changsha 410013 Hunan Peoples R China Hunan Engn Res Ctr Combinatorial Biosynth & Nat P Changsha 410011 Hunan Peoples R China Natl Engn Res Ctr Combinatorial Biosynth Drug Dis Changsha 410011 Hunan Peoples R China Scripps Res Inst Dept Chem Jupiter FL 33458 USA Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA Scripps Res Inst Dept Nat Prod Lib Initiat Jupiter FL 33458 USA
Staphylococcus aureus is one of the most common pathogens causing hospital-acquired and community-acquired infections. Methicillin-resistant S. aureus (MRSA)-formed biofilms in wounds are difficult to treat with conve... 详细信息
来源: ACS期刊 评论
Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140)
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Journal of Medicinal Chemistry 2019年 第4期62卷 1761-1780页
作者: Guerrero, Miguel Urbano, Mariangela Kim, Eun-Kyong Gamo, Ana M. Riley, Sean Abgaryan, Lusine Leaf, Nora Van Orden, Lori Jean Brown, Steven J. Xie, Jennifer Y. Porreca, Frank Cameron, Michael D. Rosen, Hugh Roberts, Edward Scripps Res Inst Dept Mol Med 10550 North Torrey Pines Rd La Jolla CA 92037 USA BlackThorn Therapeut Inc 780 Brannan St San Francisco CA 94103 USA Univ Arizona Dept Pharmacol Tucson AZ 85724 USA Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA Arkansas State Univ Coll Osteopath Med New York Inst Technol Dept Basic Sci Jonesboro AR 72446 USA
kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR ... 详细信息
来源: ACS期刊 ebsco(MEDLINE/cmedm) 评论
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
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Cell Chemical Biology 2019年 第9期26卷 1229-+页
作者: Hwang, Dobeen Nilchan, Napon Nanna, Alex R. Li, Xiaohai Cameron, Michael D. Roush, William R. Park, HaJeung Rader, Christoph Scripps Res Inst Dept Immunol & Microbiol Jupiter FL 33458 USA Scripps Res Inst Dept Chem Jupiter FL 33458 USA Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA Scripps Res Inst Xray Crystallog Core Jupiter FL 33458 USA
Homogeneous antibody-drug conjugates (ADCs) that use a highly reactive buried lysine (Lys) residue embedded in a dual variable domain (DVD)-IgG1 format can be assembled with high precision and efficiency under mild co... 详细信息
来源: ElsevierScienceDirect期刊 ElsevierScienceDirec... EBSCOASC期刊 EBSCOASC期刊 ebsco(MEDLINE/cmedm) ebsco(ASP/aph) 评论
Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model
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Proceedings of the National Academy of Sciences of the United States of America 2019年 第16期116卷 7799-7804页
作者: Angelbello, Alicia J. Rzuczek, Suzanne G. Mckee, Kendra K. Chen, Jonathan L. Olafson, Hailey Cameron, Michael D. Moss, Walter N. Wang, Eric T. Disney, Matthew D. Scripps Res Inst Dept Chem Jupiter FL 33458 USA Univ Florida Coll Med Dept Mol Genet & Microbiol Gainesville FL 32610 USA Univ Florida Coll Med Ctr NeuroGenet Gainesville FL 32610 USA Scripps Res Inst Dept Mol Med Jupiter FL 33458 USA Iowa State Univ Roy J Carver Dept Biochem Biophys & Mol Biol Ames IA 50011 USA
Myotonic dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by an expanded CTG repeat that is transcribed into r(CUG)(exp). The RNA repeat expansion sequesters regulatory proteins such as Muscleblind... 详细信息
来源: EBSCOASC期刊 EBSCOASC期刊 ebsco(MEDLINE/cmedm) 评论